Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT
Identifieur interne : 000A43 ( Main/Corpus ); précédent : 000A42; suivant : 000A44Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT
Auteurs : Vicky L. Marshall ; Cornelia B. Reininger ; Moritz Marquardt ; Jim Patterson ; Donald M. Hadley ; Wolfgang H. Oertel ; Hani T. S. Benamer ; Paul Kemp ; David Burn ; Eduardo Tolosa ; Jamie Kulisevsky ; Luis Cunha ; Durval Costa ; Jan Booij ; Klaus Tatsch ; K. Ray Chaudhuri ; Gudrun Ulm ; Oliver Pogarell ; Helmut Höffken ; Anja Gerstner ; Donald G. GrossetSource :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
English descriptors
- KwdEn :
Abstract
Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [123I]FP‐CIT (DaTSCAN™, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video‐recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [123I]FP‐CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter‐reader agreement for rating scans as normal or abnormal was high (Cohen's $\hat{\kappa}$ = 0.94–0.97). © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22108
Links to Exploration step
ISTEX:82F70FF4E28E22E0A207F3F5207597591906AA0ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT</title><author><name sortKey="Marshall, Vicky L" sort="Marshall, Vicky L" uniqKey="Marshall V" first="Vicky L." last="Marshall">Vicky L. Marshall</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Reininger, Cornelia B" sort="Reininger, Cornelia B" uniqKey="Reininger C" first="Cornelia B." last="Reininger">Cornelia B. Reininger</name><affiliation><mods:affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Marquardt, Moritz" sort="Marquardt, Moritz" uniqKey="Marquardt M" first="Moritz" last="Marquardt">Moritz Marquardt</name><affiliation><mods:affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Patterson, Jim" sort="Patterson, Jim" uniqKey="Patterson J" first="Jim" last="Patterson">Jim Patterson</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hadley, Donald M" sort="Hadley, Donald M" uniqKey="Hadley D" first="Donald M." last="Hadley">Donald M. Hadley</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation><mods:affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name><affiliation><mods:affiliation>New Cross Hospital, Wolverhampton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Kemp, Paul" sort="Kemp, Paul" uniqKey="Kemp P" first="Paul" last="Kemp">Paul Kemp</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Southampton General Hospital, Southampton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name><affiliation><mods:affiliation>Newcastle General Hospital, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation><mods:affiliation>Hospital Clinic i Provincial, Servicio de Neurologia, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Kulisevsky, Jamie" sort="Kulisevsky, Jamie" uniqKey="Kulisevsky J" first="Jamie" last="Kulisevsky">Jamie Kulisevsky</name><affiliation><mods:affiliation>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Cunha, Luis" sort="Cunha, Luis" uniqKey="Cunha L" first="Luis" last="Cunha">Luis Cunha</name><affiliation><mods:affiliation>Servico de Neurologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name><affiliation><mods:affiliation>HPP Medicina Molecular, SA, Porto, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation><mods:affiliation>Abteilung für Nuklearmedizin, Klinikum Großhadern, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation><mods:affiliation>King's College Hospital and University Hospital Lewisham, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Ulm, Gudrun" sort="Ulm, Gudrun" uniqKey="Ulm G" first="Gudrun" last="Ulm">Gudrun Ulm</name><affiliation><mods:affiliation>Paracelsius‐Elena‐Klinik, Kassel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name><affiliation><mods:affiliation>Abteilung für Klinische Neurophysiologie, Klinik für Psychiatrie der Ludwig‐Maximilians‐Universität München, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name><affiliation><mods:affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name><affiliation><mods:affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:82F70FF4E28E22E0A207F3F5207597591906AA0A</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22108</idno><idno type="url">https://api.istex.fr/document/82F70FF4E28E22E0A207F3F5207597591906AA0A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT</title><author><name sortKey="Marshall, Vicky L" sort="Marshall, Vicky L" uniqKey="Marshall V" first="Vicky L." last="Marshall">Vicky L. Marshall</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Reininger, Cornelia B" sort="Reininger, Cornelia B" uniqKey="Reininger C" first="Cornelia B." last="Reininger">Cornelia B. Reininger</name><affiliation><mods:affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Marquardt, Moritz" sort="Marquardt, Moritz" uniqKey="Marquardt M" first="Moritz" last="Marquardt">Moritz Marquardt</name><affiliation><mods:affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Patterson, Jim" sort="Patterson, Jim" uniqKey="Patterson J" first="Jim" last="Patterson">Jim Patterson</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hadley, Donald M" sort="Hadley, Donald M" uniqKey="Hadley D" first="Donald M." last="Hadley">Donald M. Hadley</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation><mods:affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name><affiliation><mods:affiliation>New Cross Hospital, Wolverhampton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Kemp, Paul" sort="Kemp, Paul" uniqKey="Kemp P" first="Paul" last="Kemp">Paul Kemp</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Southampton General Hospital, Southampton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name><affiliation><mods:affiliation>Newcastle General Hospital, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation><mods:affiliation>Hospital Clinic i Provincial, Servicio de Neurologia, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Kulisevsky, Jamie" sort="Kulisevsky, Jamie" uniqKey="Kulisevsky J" first="Jamie" last="Kulisevsky">Jamie Kulisevsky</name><affiliation><mods:affiliation>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Cunha, Luis" sort="Cunha, Luis" uniqKey="Cunha L" first="Luis" last="Cunha">Luis Cunha</name><affiliation><mods:affiliation>Servico de Neurologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Costa, Durval" sort="Costa, Durval" uniqKey="Costa D" first="Durval" last="Costa">Durval Costa</name><affiliation><mods:affiliation>HPP Medicina Molecular, SA, Porto, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><affiliation><mods:affiliation>Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation><mods:affiliation>Abteilung für Nuklearmedizin, Klinikum Großhadern, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation><mods:affiliation>King's College Hospital and University Hospital Lewisham, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Ulm, Gudrun" sort="Ulm, Gudrun" uniqKey="Ulm G" first="Gudrun" last="Ulm">Gudrun Ulm</name><affiliation><mods:affiliation>Paracelsius‐Elena‐Klinik, Kassel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name><affiliation><mods:affiliation>Abteilung für Klinische Neurophysiologie, Klinik für Psychiatrie der Ludwig‐Maximilians‐Universität München, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hoffken, Helmut" sort="Hoffken, Helmut" uniqKey="Hoffken H" first="Helmut" last="Höffken">Helmut Höffken</name><affiliation><mods:affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gerstner, Anja" sort="Gerstner, Anja" uniqKey="Gerstner A" first="Anja" last="Gerstner">Anja Gerstner</name><affiliation><mods:affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation><mods:affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15">2009-03-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="500">500</biblScope><biblScope unit="page" to="508">508</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">82F70FF4E28E22E0A207F3F5207597591906AA0A</idno><idno type="DOI">10.1002/mds.22108</idno><idno type="ArticleID">MDS22108</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>SPECT</term><term>SWEDD</term><term>[123I]FP‐CIT</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [123I]FP‐CIT (DaTSCAN™, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video‐recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [123I]FP‐CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter‐reader agreement for rating scans as normal or abnormal was high (Cohen's $\hat{\kappa}$ = 0.94–0.97). © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Vicky L. Marshall MD</name><affiliations><json:string>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string></affiliations></json:item><json:item><name>Cornelia B. Reininger MD</name><affiliations><json:string>General Electric Healthcare, Clinical Research & Development, Munich, Germany</json:string></affiliations></json:item><json:item><name>Moritz Marquardt MSc</name><affiliations><json:string>General Electric Healthcare, Clinical Research & Development, Munich, Germany</json:string></affiliations></json:item><json:item><name>Jim Patterson PhD</name><affiliations><json:string>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string></affiliations></json:item><json:item><name>Donald M. Hadley PhD</name><affiliations><json:string>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string></affiliations></json:item><json:item><name>Wolfgang H. Oertel MD</name><affiliations><json:string>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Hani T.S. Benamer PhD</name><affiliations><json:string>New Cross Hospital, Wolverhampton, United Kingdom</json:string></affiliations></json:item><json:item><name>Paul Kemp MD</name><affiliations><json:string>Department of Nuclear Medicine, Southampton General Hospital, Southampton, United Kingdom</json:string></affiliations></json:item><json:item><name>David Burn MD</name><affiliations><json:string>Newcastle General Hospital, Newcastle upon Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>Eduardo Tolosa MD</name><affiliations><json:string>Hospital Clinic i Provincial, Servicio de Neurologia, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Jamie Kulisevsky MD</name><affiliations><json:string>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Luis Cunha MD</name><affiliations><json:string>Servico de Neurologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal</json:string></affiliations></json:item><json:item><name>Durval Costa MD</name><affiliations><json:string>HPP Medicina Molecular, SA, Porto, Portugal</json:string></affiliations></json:item><json:item><name>Jan Booij MD</name><affiliations><json:string>Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, Netherlands</json:string></affiliations></json:item><json:item><name>Klaus Tatsch MD</name><affiliations><json:string>Abteilung für Nuklearmedizin, Klinikum Großhadern, München, Germany</json:string></affiliations></json:item><json:item><name>K. Ray Chaudhuri MD</name><affiliations><json:string>King's College Hospital and University Hospital Lewisham, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Gudrun Ulm MD</name><affiliations><json:string>Paracelsius‐Elena‐Klinik, Kassel, Germany</json:string></affiliations></json:item><json:item><name>Oliver Pogarell MD</name><affiliations><json:string>Abteilung für Klinische Neurophysiologie, Klinik für Psychiatrie der Ludwig‐Maximilians‐Universität München, München, Germany</json:string></affiliations></json:item><json:item><name>Helmut Höffken MD</name><affiliations><json:string>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Anja Gerstner MD</name><affiliations><json:string>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Donald G. Grosset MD</name><affiliations><json:string>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string><json:string>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>[123I]FP‐CIT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SPECT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SWEDD</value></json:item></subject><articleId><json:string>MDS22108</json:string></articleId><language><json:string>eng</json:string></language><abstract>Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [123I]FP‐CIT (DaTSCAN™, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video‐recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [123I]FP‐CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter‐reader agreement for rating scans as normal or abnormal was high (Cohen's $\hat{\kappa}$ = 0.94–0.97). © 2008 Movement Disorder Society</abstract><qualityIndicators><score>7.7</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1604</abstractCharCount><pdfWordCount>5038</pdfWordCount><pdfCharCount>31851</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>225</abstractWordCount></qualityIndicators><title>Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>9</total><last>508</last><first>500</first></pages><issn><json:string>0885-3185</json:string></issn><issue>4</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22108</json:string></doi><id>82F70FF4E28E22E0A207F3F5207597591906AA0A</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/82F70FF4E28E22E0A207F3F5207597591906AA0A/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/82F70FF4E28E22E0A207F3F5207597591906AA0A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/82F70FF4E28E22E0A207F3F5207597591906AA0A/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Financial support has been received by Klaus Tatsch, Jan Booij, Paul Kemp, Ray Chaudhuri, Wolfgang Oertel, Jim Patterson, Hani Benamer, Oliver Pogarell, Vicky Marshall, and Donald Grosset from GE Healthcare (manufacturers of [123I]FP‐CIT).</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT</title><author><persName><forename type="first">Vicky L.</forename><surname>Marshall</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, Glasgow, G51 4TF, Scotland, UK</p></note><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation></author><author><persName><forename type="first">Cornelia B.</forename><surname>Reininger</surname></persName><roleName type="degree">MD</roleName><affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</affiliation></author><author><persName><forename type="first">Moritz</forename><surname>Marquardt</surname></persName><roleName type="degree">MSc</roleName><affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</affiliation></author><author><persName><forename type="first">Jim</forename><surname>Patterson</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation></author><author><persName><forename type="first">Donald M.</forename><surname>Hadley</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation></author><author><persName><forename type="first">Wolfgang H.</forename><surname>Oertel</surname></persName><roleName type="degree">MD</roleName><affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Hani T.S.</forename><surname>Benamer</surname></persName><roleName type="degree">PhD</roleName><affiliation>New Cross Hospital, Wolverhampton, United Kingdom</affiliation></author><author><persName><forename type="first">Paul</forename><surname>Kemp</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Nuclear Medicine, Southampton General Hospital, Southampton, United Kingdom</affiliation></author><author><persName><forename type="first">David</forename><surname>Burn</surname></persName><roleName type="degree">MD</roleName><affiliation>Newcastle General Hospital, Newcastle upon Tyne, United Kingdom</affiliation></author><author><persName><forename type="first">Eduardo</forename><surname>Tolosa</surname></persName><roleName type="degree">MD</roleName><affiliation>Hospital Clinic i Provincial, Servicio de Neurologia, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Jamie</forename><surname>Kulisevsky</surname></persName><roleName type="degree">MD</roleName><affiliation>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Luis</forename><surname>Cunha</surname></persName><roleName type="degree">MD</roleName><affiliation>Servico de Neurologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal</affiliation></author><author><persName><forename type="first">Durval</forename><surname>Costa</surname></persName><roleName type="degree">MD</roleName><affiliation>HPP Medicina Molecular, SA, Porto, Portugal</affiliation></author><author><persName><forename type="first">Jan</forename><surname>Booij</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, Netherlands</affiliation></author><author><persName><forename type="first">Klaus</forename><surname>Tatsch</surname></persName><roleName type="degree">MD</roleName><affiliation>Abteilung für Nuklearmedizin, Klinikum Großhadern, München, Germany</affiliation></author><author><persName><forename type="first">K. Ray</forename><surname>Chaudhuri</surname></persName><roleName type="degree">MD</roleName><affiliation>King's College Hospital and University Hospital Lewisham, London, United Kingdom</affiliation></author><author><persName><forename type="first">Gudrun</forename><surname>Ulm</surname></persName><roleName type="degree">MD</roleName><affiliation>Paracelsius‐Elena‐Klinik, Kassel, Germany</affiliation></author><author><persName><forename type="first">Oliver</forename><surname>Pogarell</surname></persName><roleName type="degree">MD</roleName><affiliation>Abteilung für Klinische Neurophysiologie, Klinik für Psychiatrie der Ludwig‐Maximilians‐Universität München, München, Germany</affiliation></author><author><persName><forename type="first">Helmut</forename><surname>Höffken</surname></persName><roleName type="degree">MD</roleName><affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Anja</forename><surname>Gerstner</surname></persName><roleName type="degree">MD</roleName><affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Donald G.</forename><surname>Grosset</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="500">500</biblScope><biblScope unit="page" to="508">508</biblScope></imprint></monogr><idno type="istex">82F70FF4E28E22E0A207F3F5207597591906AA0A</idno><idno type="DOI">10.1002/mds.22108</idno><idno type="ArticleID">MDS22108</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [123I]FP‐CIT (DaTSCAN™, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video‐recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [123I]FP‐CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter‐reader agreement for rating scans as normal or abnormal was high (Cohen's $\hat{\kappa}$ = 0.94–0.97). © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>[123I]FP‐CIT</term></item><item><term>SPECT</term></item><item><term>SWEDD</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-07-09">Received</change><change when="2008-04-01">Registration</change><change when="2009-03-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/82F70FF4E28E22E0A207F3F5207597591906AA0A/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley" registered="yes">10.1002/mds.v24:4</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2009-03-15">15 March 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="40" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22108</doi><idGroup><id type="unit" value="MDS22108"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptAccepted" date="2008-04-01"></event><event type="manuscriptReceived" date="2008-07-09"></event><event type="firstOnline" date="2008-12-31"></event><event type="publishedOnlineFinalForm" date="2009-03-24"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2008-12-31"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText mathml2tex" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">500</numbering><numbering type="pageLast">508</numbering></numberingGroup><correspondenceTo>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, Glasgow, G51 4TF, Scotland, UK</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22108.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="5"></count><count type="referenceTotal" number="33"></count><count type="wordTotal" number="6318"></count></countGroup><titleGroup><title type="main" xml:lang="en">Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [<sup>123</sup>I]FP‐CIT SPECT<link href="#fn8"></link></title><title type="short" xml:lang="en">Parkinson's Disease is Overdiagnosed at Baseline</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>Vicky L.</givenNames><familyName>Marshall</familyName><degrees>MD</degrees></personName><contactDetails><email>v.marshall@clinmed.gla.ac.uk</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Cornelia B.</givenNames><familyName>Reininger</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Moritz</givenNames><familyName>Marquardt</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Jim</givenNames><familyName>Patterson</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Donald M.</givenNames><familyName>Hadley</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Wolfgang H.</givenNames><familyName>Oertel</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Hani T.S.</givenNames><familyName>Benamer</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Paul</givenNames><familyName>Kemp</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af8"><personName><givenNames>David</givenNames><familyName>Burn</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Eduardo</givenNames><familyName>Tolosa</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Jamie</givenNames><familyName>Kulisevsky</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Luis</givenNames><familyName>Cunha</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Durval</givenNames><familyName>Costa</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af13"><personName><givenNames>Jan</givenNames><familyName>Booij</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af14"><personName><givenNames>Klaus</givenNames><familyName>Tatsch</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af15"><personName><givenNames>K. Ray</givenNames><familyName>Chaudhuri</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af16"><personName><givenNames>Gudrun</givenNames><familyName>Ulm</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af17"><personName><givenNames>Oliver</givenNames><familyName>Pogarell</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au19" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Helmut</givenNames><familyName>Höffken</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au20" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Anja</givenNames><familyName>Gerstner</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au21" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Donald G.</givenNames><familyName>Grosset</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="DE" type="organization"><unparsedAffiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="GB" type="organization"><unparsedAffiliation>New Cross Hospital, Wolverhampton, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="GB" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Southampton General Hospital, Southampton, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="GB" type="organization"><unparsedAffiliation>Newcastle General Hospital, Newcastle upon Tyne, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="ES" type="organization"><unparsedAffiliation>Hospital Clinic i Provincial, Servicio de Neurologia, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="ES" type="organization"><unparsedAffiliation>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="PT" type="organization"><unparsedAffiliation>Servico de Neurologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal</unparsedAffiliation></affiliation><affiliation xml:id="af12" countryCode="PT" type="organization"><unparsedAffiliation>HPP Medicina Molecular, SA, Porto, Portugal</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="NL" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="DE" type="organization"><unparsedAffiliation>Abteilung für Nuklearmedizin, Klinikum Großhadern, München, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="GB" type="organization"><unparsedAffiliation>King's College Hospital and University Hospital Lewisham, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af16" countryCode="DE" type="organization"><unparsedAffiliation>Paracelsius‐Elena‐Klinik, Kassel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af17" countryCode="DE" type="organization"><unparsedAffiliation>Abteilung für Klinische Neurophysiologie, Klinik für Psychiatrie der Ludwig‐Maximilians‐Universität München, München, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">[<sup>123</sup>I]FP‐CIT</keyword><keyword xml:id="kwd3">SPECT</keyword><keyword xml:id="kwd4">SWEDD</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [<sup>123</sup>I]FP‐CIT (DaTSCAN™, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video‐recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [<sup>123</sup>I]FP‐CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter‐reader agreement for rating scans as normal or abnormal was high (Cohen's <span type="tex">$\hat{\kappa}$<inlineGraphic alt="equation image" location="equation/tex2gif-ueqn-1.gif" href=""></inlineGraphic></span> = 0.94–0.97). © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn8"><p>Potential conflict of interest: Financial support has been received by Klaus Tatsch, Jan Booij, Paul Kemp, Ray Chaudhuri, Wolfgang Oertel, Jim Patterson, Hani Benamer, Oliver Pogarell, Vicky Marshall, and Donald Grosset from GE Healthcare (manufacturers of [<sup>123</sup>I]FP‐CIT).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Parkinson's Disease is Overdiagnosed at Baseline</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [</title></titleInfo><name type="personal"><namePart type="given">Vicky L.</namePart><namePart type="family">Marshall</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><description>Correspondence: Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, Glasgow, G51 4TF, Scotland, UK</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cornelia B.</namePart><namePart type="family">Reininger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Moritz</namePart><namePart type="family">Marquardt</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>General Electric Healthcare, Clinical Research & Development, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jim</namePart><namePart type="family">Patterson</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald M.</namePart><namePart type="family">Hadley</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang H.</namePart><namePart type="family">Oertel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hani T.S.</namePart><namePart type="family">Benamer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>New Cross Hospital, Wolverhampton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Kemp</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Nuclear Medicine, Southampton General Hospital, Southampton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Burn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Newcastle General Hospital, Newcastle upon Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo</namePart><namePart type="family">Tolosa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Hospital Clinic i Provincial, Servicio de Neurologia, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jamie</namePart><namePart type="family">Kulisevsky</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Servicio de Neurologia and CIBERNED, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luis</namePart><namePart type="family">Cunha</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Servico de Neurologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Durval</namePart><namePart type="family">Costa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>HPP Medicina Molecular, SA, Porto, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Booij</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Klaus</namePart><namePart type="family">Tatsch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Abteilung für Nuklearmedizin, Klinikum Großhadern, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. Ray</namePart><namePart type="family">Chaudhuri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>King's College Hospital and University Hospital Lewisham, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gudrun</namePart><namePart type="family">Ulm</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Paracelsius‐Elena‐Klinik, Kassel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Oliver</namePart><namePart type="family">Pogarell</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Abteilung für Klinische Neurophysiologie, Klinik für Psychiatrie der Ludwig‐Maximilians‐Universität München, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helmut</namePart><namePart type="family">Höffken</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anja</namePart><namePart type="family">Gerstner</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Medizinisches Zentrum für Nervenheilkunde/Klinik für Neurologie/Abteilung für Nuklearmedizin, Klinikum der Phillips‐Universität Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald G.</namePart><namePart type="family">Grosset</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Neuroradiology, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><affiliation>Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-03-15</dateIssued><dateCaptured encoding="w3cdtf">2008-07-09</dateCaptured><dateValid encoding="w3cdtf">2008-04-01</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">5</extent><extent unit="references">33</extent><extent unit="words">6318</extent></physicalDescription><abstract lang="en">Overdiagnosis of Parkinson's disease (PD) is suggested by specialist review of community diagnosis, and in postmortem studies. In specialist centers 4 to 15% of patients entered into clinical trials as early PD do not have functional imaging support for a PD diagnosis. In a European multicenter, prospective, longitudinal study, we compared clinical diagnosis with functional SPECT imaging using [123I]FP‐CIT (DaTSCAN™, GE Healthcare). Repeat observations were performed over 3 years in patients with tremor and/or parkinsonism in whom there was initial diagnostic uncertainty between degenerative parkinsonism and nondegenerative tremor disorders. Video‐recording of clinical features was scored independently of functional imaging results by two blinded clinicians at 36 months (= gold standard clinical diagnosis). Three readers, unaware of the clinical diagnosis, classified the images as normal or abnormal by visual inspection. The main endpoint was the sensitivity and specificity of SPECT imaging at baseline compared with the gold standard. In 99 patients completing the three serial assessments, on‐site clinical diagnosis overdiagnosed degenerative parkinsonism at baseline in diagnostically uncertain cases compared with the gold standard clinical diagnosis (at 36 months), the latter giving a sensitivity of 93% and specificity of 46%. The corresponding baseline [123I]FP‐CIT SPECT results showed a mean sensitivity of 78% and a specificity of 97%. Inter‐reader agreement for rating scans as normal or abnormal was high (Cohen's $\hat{\kappa}$ = 0.94–0.97). © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Financial support has been received by Klaus Tatsch, Jan Booij, Paul Kemp, Ray Chaudhuri, Wolfgang Oertel, Jim Patterson, Hani Benamer, Oliver Pogarell, Vicky Marshall, and Donald Grosset from GE Healthcare (manufacturers of [123I]FP‐CIT).</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>[123I]FP‐CIT</topic><topic>SPECT</topic><topic>SWEDD</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>500</start><end>508</end><total>9</total></extent></part></relatedItem><identifier type="istex">82F70FF4E28E22E0A207F3F5207597591906AA0A</identifier><identifier type="DOI">10.1002/mds.22108</identifier><identifier type="ArticleID">MDS22108</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A43 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000A43 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:82F70FF4E28E22E0A207F3F5207597591906AA0A
|texte= Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT
}}
| This area was generated with Dilib version V0.6.23. |  |